Cyclooxygenase-2 and its regulation in inflammation

Cyclooxygenase-2 and its regulation in inflammation

Transient up-regulation of spinal cyclooxygenase-2 and neuronal nitric oxide synthase following surgical inflammation.

BACKGROUND Surgery induces pain and hyperalgesia postoperatively. The products of cyclooxygenases and nitric oxide synthase (NOS) have been implicated in the development of inflammatory pain and hyperalgesia experimentally, and the use of drugs clinically that modify cyclooxygenase activity has been advocated in the management of perioperative pain. However, regulation of these enzymes followin...

Nitric oxide-mediated negative regulation of cyclooxygenase-2 induction in vascular inflammation.

ATHEROSCLEROSIS AND OTHER metabolic disorders such as obesity, traditionally considered as mere lipid store disorders and strongly associated with increased cardiovascular risk and morbidity, are currently accepted as inflammatory diseases that lead to a chronic inflammatory state of the vascular wall (12). Cyclooxygenase (COX)-derived prostaglandins are important mediators of the local inflamm...

Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats.

It has been reported that cyclooxygenase-2 (COX-2) may play a crucial role in gastric ulcer healing. We examined the localization of COX-2 and the regulation of COX-2 mRNA expression in acetic acid ulcers in rats. PGE2 production was elevated in ulcerated tissue but not in intact tissue. COX-2 mRNA expression was induced in only the ulcerated tissue, and COX-2 protein was found in fibroblasts, ...

Cyclooxygenase-2 gene transcription in a macrophage model of inflammation.

Infections involving LPS-bearing, Gram-negative bacteria can lead to acute inflammation and septic shock. Cyclooxygenase-2 (COX-2), the target of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, is importantly involved in these responses. We examined the dynamics of COX-2 gene expression in RAW264.7 murine macrophages treated with LPS as a model for COX-2 gene expression dur...